High resolution 3D dosimetry for microbeam radiation therapy using optical CT

8th International Conference on 3D Radiation Dosimetry

McErlean, C.^1 ; Bräuer-Krisch, E.^2 ; Adamovics, J.^3,6 ; Leach, M.O.^1,4 ; Doran, S.J.^1,5

CRUK Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom^1

European Synchrotron Radiation Facility, Grenoble, France^2

Department of Chemistry and Biology, Rider University, Lawrenceville

NJ, United States^3

Clinical Magnetic Resonance Research Group, Royal Marsden NHS Trust, United Kingdom^4

Department of Physics, University of Surrey, Guildford, United Kingdom^5

Heuris Pharma, LLC, 412 Sunset Rd., Skillman

NJ

08558, United States^6

关键词: High resolution;    Irradiation geometries;    Microbeam Radiation Therapy;    Optical computed tomography;    Optical CT;    Peak-to-valley dose ratios;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/573/1/012032/pdf
DOI  :  10.1088/1742-6596/573/1/012032

来源: IOP

【 摘 要 】

Optical Computed Tomography (CT) is a promising technique for dosimetry of Microbeam Radiation Therapy (MRT), providing high resolution 3D dose maps. Here different MRT irradiation geometries are visualised showing the potential of Optical CT as a tool for future MRT trials. The Peak-to-Valley dose ratio (PVDR) is calculated to be 7 at a depth of 3mm in the radiochromic dosimeter PRESAGE®. This is significantly lower than predicted values and possible reasons for this are discussed.