Study of low-frequency dynamics of short peptides by Brillouin light scattering and Monte-Carlo global energy minimization

16th Russian Youth Conference on Physics and Astronomy

物理学;天文学

Vashchenkov, V.E.^1,2 ; Fedoseev, A.I.^1,2 ; Petukhov, M.G.^3,4 ; Khavinson, V Kh^5 ; Savvateeva-Popova, E.V.^2,5 ; Lushnikov, S.G.^1,2

Ioffe Physical Technical Institute, St.Petersburg, Russia^1

St.Petersburg State University, St.Petersburg, Russia^2

St.Petersburg State Polytechnical University, St.Petersburg, Russia^3

Petersburg Institute of Nuclear Physics, Gatchina, Leningrad district, Russia^4

Pavlov Institute of Physiology, St.Petersburg, Russia^5

关键词: Brillouin light scattering;    Di-peptides;    Global energy;    High temperature;    Hypersound velocity;    Low frequency dynamics;    Molecular simulations;    Tetra peptide;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/572/1/012015/pdf
DOI  :  10.1088/1742-6596/572/1/012015

学科分类：天文学(综合)

来源: IOP

【 摘 要 】

Brillouin light scattering studies of the behavior of hypersound velocity in solutions of short peptides Asp-Ser, Glu-Asp-Arg, Ala-Glu-Asp-Leu with widely varying concentrations at temperatures ranging from 295 to 360K are presented. As shown by analysis of experimental data and molecular simulation, the dipeptide Asp-Ser is characterized by formation of dimers which decompose at high temperatures. High-concentration solutions of tri- and tetrapeptides form aggregates at high temperatures which are preserved on cooling.