Muonium response to oxygen content in biological aqueous solutions for cancer research

13th International Conference on Muon Spin Rotation, Relaxation and Resonance

Pant, A.D.^1 ; Nagamine, K.^2,3,4 ; Shiraki, I.^1 ; Torikai, E.^1 ; Shimomura, K.^4 ; Pratt, F.L.^5 ; Ariga, H.^6 ; Ishida, K.^7 ; Schultz, J.S.^8

Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 4-3-11 Takeda, Kofu

400-8511, Japan^1

Atomic Physics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama

351-0198, Japan^2

Physics and Astronomy, University of California, Riverside, United States^3

Muon Science Laboratory, IMSS. KEK, Tsukuba, Oho, Ibaraki, Japan^4

ISIS, Rutherford Appleton Laboratory, Oxford, United Kingdom^5

Catalysis Research Centre, Hokkaido University, Sapporo, Japan^6

Advanced Meson Science Laboratory, RIKEN, 2-1 Hirosawa, Wako, Japan^7

Department of Bio-engineering, University of California, Riverside, United States^8

关键词: Cancer research;    Concentration-dependent;    Oxygen content;    Oxygen levels;    Radiation treatments;    Spin relaxation;    Systematic study;    Tris-buffered salines;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/551/1/012043/pdf
DOI  :  10.1088/1742-6596/551/1/012043

来源: IOP

【 摘 要 】

Muonium (Mu), which is known to exhibit a characteristic concentration dependent spin relaxation change when impacting molecular oxygen dissolved in water, was found to show a similar behaviour in aqueous solutions of Tris Buffered Saline (TBS), albumin, serum, and hemoglobin (Hb). These effects, along with the interaction of Mu with deoxy-Hb (which is modulated by oxygen by the formation of oxy-Hb) suggest that the muon method can be applied to systematic studies of oxygen dependent effects in biological systems. This muon method may particularly be applicable at low (hypoxic) oxygen levels, an important consideration in the radiation treatment of cancer.