Physical Modeling of Microtubules Network

4th International Workshop on New Computational Methods for Inverse Problems

物理学;计算机科学

Allain, Pierre^1 ; Kervrann, Charles^1

Inria, Centre Rennes-Bretagne Atlantique, Campus Universitaire de Beaulieu, Rennes Cedex

35042, France^1

关键词: Cell organization;    Cellular process;    Cytoskeletons;    Data assimilation techniques;    Euler Bernoulli beam theory;    Overall-model;    Physical model;    Vesicular transport;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/542/1/012005/pdf
DOI  :  10.1088/1742-6596/542/1/012005

学科分类：计算机科学（综合）

来源: IOP

【 摘 要 】

Microtubules (MT) are highly dynamic tubulin polymers that are involved in many cellular processes such as mitosis, intracellular cell organization and vesicular transport. Nevertheless, the modeling of cytoskeleton and MT dynamics based on physical properties is difficult to achieve. Using the Euler-Bernoulli beam theory, we propose to model the rigidity of microtubules on a physical basis using forces, mass and acceleration. In addition, we link microtubules growth and shrinkage to the presence of molecules (e.g. GTP-tubulin) in the cytosol. The overall model enables linking cytosol to microtubules dynamics in a constant state space thus allowing usage of data assimilation techniques.