Mechanical and histological characterization of trachea tissue subjected to blast-type pressures

18th APS-SCCM; 24th AIRAPT

Butler, B.J.^1,2 ; Bo, C.^1,3 ; Tucker, A.W.^4 ; Jardine, A.P.^2 ; Proud, W.G.^1,3 ; Williams, A.^4 ; Brown, K.A.^1,2,5

Royal British Legion Centre for Blast Injury Studies, Imperial College London, London, United Kingdom^1

Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom^2

Institute of Shock Physics, Imperial College London, London, United Kingdom^3

Department of Veterinary Medicine, Cambridge University, Cambridge, United Kingdom^4

Department of Chemistry, University of Texas, Austin, United States^5

关键词: Air liquid interfaces;    Blast loading;    Cellular response;    High strain rates;    Over-pressures;    Polytrauma;    Pressure loading;    Tissue specimens;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/500/18/182007/pdf
DOI  :  10.1088/1742-6596/500/18/182007

来源: IOP

【 摘 要 】

Injuries to the respiratory system can be a component of polytrauma in blast-loading injuries. Tissues located at air-liquid interfaces, including such tissues in the respiratory system, are particularly vulnerable to damage by blast overpressures. There is a lack of information about the mechanical and cellular responses that contribute to the damage of this class of tissues subjected to the high strain rates associated with blast loading. Here, we describe the results of dynamic blast-like pressure loading tests at high strain rates on freshly harvested ex vivo trachea tissue specimens.