Assessing local outcomes in heterogeneous gliomas

17th International Conference on the Use of Computers in Radiation Therapy

物理学;计算机科学

Dowson, Nicholas^1 ; Thomas, Paul^2,3 ; Gal, Yaniv^3 ; Fay, Michael^2,3,4 ; Jeffree, Rosalind L^2 ; Winter, Craig^2 ; Coulthard, Alan^2,3 ; Smith, Jye^2,3 ; Bourgeat, Pierrick^1 ; Salvado, Olivier^1,3 ; Crozier, Stuart^3 ; Rose, Stephen^1,3

Australian E-Health Research Centre (CSIRO), UQ Health Sciences Building, Royal Brisbane and Women's Hospital, Herston, QLD 4053, Australia^1

Departments of Nuclear Medicine, Radiology, Radiation Oncology And, Neurosurgery, Royal Brisbane and Women's Hospital, Herston, QLD 4053, Australia^2

School of IT and Elec. Eng. University of Queensland, St Lucia, 4072, QLD, Australia^3

Eberhard Karls Universität Tübingen, Germany^4

关键词: Contrast-enhanced;    l-Phenylalanine;    Local analysis;    Overall survival;    Positive correlations;    Treatment outcomes;    Treatment planning;    Treatment plans;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/489/1/012073/pdf
DOI  :  10.1088/1742-6596/489/1/012073

学科分类：计算机科学（综合）

来源: IOP

【 摘 要 】

Tumours are known to be heterogeneous, yet typical treatment plans consider them as a single unit. This may influence treatment outcomes. However, treatment cannot be customised to intra-tumour variation without a method to establish outcomes at an intra-tumour scale. This work proposes a method to both assess and measure outcomes locally within tumours. Methods: Four patients were scanned at two post-surgery time points using contrast enhanced MRI and 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (18F-DOPA) PET. The shell of active tumour tissue is divided into a set of small subregions at both time points. Local outcome is measured from changes in subregion volume over time. The utility of the proposed approach is evaluated by measuring the correlation between PET uptake and documented growth. Correlation with overall survival time was also examined. Results: Local outcomes were heterogeneous and evidence of a positive correlation between local 18F-DOPA uptake and local progression was observed. Conclusions: Given that intra-tumour outcomes are heterogeneous the consistently positive correlation between FDOPA uptake and progression, local analysis of tumours could prove useful for treatment planning.