Theoretical characterisation of the radial and translational motion of coated microbubbles under acoustic excitation

11th Anglo-French Physical Acoustics Conference

Harfield, C.J.^1 ; Ovenden, N.C.^2 ; Memoli, G.^3 ; Jones, P.H.^4 ; Stride, E.P.J.^1

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, OX3 7DQ, United Kingdom^1

Department of Mathematics, University College London, Gower Street, WC1E 6BT London, United Kingdom^2

National Physical Laboratory, Teddington, Middlesex, TW11 0LW, United Kingdom^3

Department of Physics and Astronomy, University College London, Gower Street, WC1E 6BT London, United Kingdom^4

关键词: Acoustic excitation;    Advanced diagnostics;    Bubble behaviour;    Current diagnostics;    Elastic response;    Quantitative measurement;    Translational motions;    Ultrasound contrast agent;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/457/1/012001/pdf
DOI  :  10.1088/1742-6596/457/1/012001

来源: IOP

【 摘 要 】

Ultrasound contrast agents, in the form of coated microbubbles, are a powerful tool in current diagnostic imaging. Given their sensitive dynamic response they also have the potential to be used for quantitative measurements of the properties of the surrounding tissue (e.g. percentage perfusion or blood pressure). For this potential to be realised, however, the theoretical descriptions of bubble behaviour, in particular the constitutive equations for the microbubble shell, need to be improved and a method needs to be developed for the accurate characterisation of individual bubbles. In this paper the first steps are taken towards deriving a complete model for the coupled radial and translational motion of a coated bubble. It is then shown that with this model the bubble can be characterised by a unique set of parameters describing the bubble shell corresponding to its viscous and elastic response. This uniqueness will enable the model to be used to interpret experimental data and quantify these parameters for which accurate values are currently lacking but which are critical to predicting bubble response and hence enabling advanced diagnostic applications.