PALS: A unique probe for the molecular organisation of biopolymer matrices

16th International Conference on Positron Annihilation

Roussenova, M.^1 ; Alam, M.A.^1

H. H. Wills Physics Laboratory, University of Bristol, Tyndall Avenue, Bristol BS8 1TL, United Kingdom^1

关键词: Composition structure;    Drug delivery system;    Encapsulants;    Macroscopic properties;    Matrix composition;    Molecular packings;    Positron annihilation lifetime spectroscopy;    Thermodynamic state;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/443/1/012044/pdf
DOI  :  10.1088/1742-6596/443/1/012044

来源: IOP

【 摘 要 】

This short review aims to illustrate the versatility of Positron Annihilation Lifetime Spectroscopy (PALS) when utilized for the characterization of biopolymers (e.g.: starch, fractionated maltooligomers, gelatin and cellulose derivatives) commonly used for the formulation of pharmaceutical encapsulants. By showing examples from a number of recent PALS studies, we illustrate that this technique can be used to probe the changes in thermodynamic state and molecular packing for a wide range of biopolymer matrices as a function of temperature, matrix composition and water content. This provides a basis for establishing composition-structure-property relationships for these materials, which would eventually enable the rational control of their macroscopic properties and the design of optimal encapsulating matrices and intelligent drug delivery systems.