Radiation damage of biomolecules (RADAM) database development: current status

International Conference on Dynamics of Systems on the Nanoscale 2012

Denifl, S.^1 ; Garcia, G.^2,3 ; Huber, B.A.^4 ; Marinkovic´, B.P.^5,11 ; Mason, N.^6 ; Postler, J.^1 ; Rabus, H.^7 ; Rixon, G.^6 ; Solov'yov, A.V.^8,10 ; Suraud, E.^9 ; Yakubovich, A.V.^8,10

Institut für Ionenphysik und Angewandte Physik, Technikerstr. 25/3, A-6020 Innsbruck, Austria^1

Instituto de Física Fundamental, Consejo Superior de Investigaciones Científicas, (CSIC), Serrano 113-bis, 28006 Madrid, Spain^2

Centre for Medical Radiation Physics, University of Wollongong, NSW 2522, Australia^3

Centre de Recherche Sur Les Ions, la Matière et la Photonique (CIMAP), Bd Henri Becquerel, 14070 Caen Cedex 05, France^4

Institute of Physics, University of Belgrade, Pregrevica 118, 11080 Belgrade, Serbia^5

Open University, Faculty of Science, Walton Hall, Milton Keynes, MK7 6AA, United Kingdom^6

Physikalisch-Technische Bundesanstalt, Bundesallee 100, 38116 Braunschweig, Germany^7

Frankfurt Institute for Advanced Studies, Ruth-Moufang Str. 1, 60438, Frankfurt am Main, Germany^8

Laboratoire de Physique Théorique, CNRS, Université Paul Sabatier, 118 Routre de Narbonne, 31062 Toulouse Cedex, France

(10) A.F. Ioffe Physical-Technical Institute, Polytechnicheskaya 26, 194021, St. Petersburg, Russia

(11) Advanced School for Electrical Engineering and Informatics, 11030 Belgrade, Serbia^9

关键词: Biological molecule;    Chemical and biologicals;    Database development;    Dielectric response;    Electron attachment;    Excitation cross section;    Mathematical equations;    Research communities;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/438/1/012016/pdf
DOI  :  10.1088/1742-6596/438/1/012016

来源: IOP

【 摘 要 】

Ion beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue, while maximizing cell killing within the tumour. However, as the underlying dependent physical, chemical and biological processes are too complex to treat them on a purely analytical level, most of our current and future understanding will rely on computer simulations, based on mathematical equations, algorithms and last, but not least, on the available atomic and molecular data. The viability of the simulated output and the success of any computer simulation will be determined by these data, which are treated as the input variables in each computer simulation performed. The radiation research community lacks a complete database for the cross sections of all the different processes involved in ion beam induced damage: ionization and excitation cross sections for ions with liquid water and biological molecules, all the possible electron - medium interactions, dielectric response data, electron attachment to biomolecules etc. In this paper we discuss current progress in the creation of such a database, outline the roadmap of the project and review plans for the exploitation of such a database in future simulations.