Ionization of biomolecular targets by ion impact: input data for radiobiological applications

International Conference on Dynamics of Systems on the Nanoscale 2012

De Vera, Pablo^1,2 ; Abril, Isabel^1 ; Garcia-Molina, Rafael^3 ; Solov'yov, Andrey V.^2,4

Departament de Física Aplicada, Universitat d'Alacant, E-03080 Alacant, Spain^1

Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Germany^2

Departamento de Física, Centro de Investigacíon en Óptica Y Nanofísica, Universidad de Murcia, E-30100 Murcia, Spain^3

A.F. Ioffe Physical-Technical Institute, Politechnicheskaya 26, 194021 St. Petersburg, Russia^4

关键词: Bioorganic compounds;    Dielectric formalism;    Ion-impact ionization;    Ionization efficiency;    Optical energy loss;    Secondary electrons;    Semi-empirical modeling;    Total ionization cross sections;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/438/1/012015/pdf
DOI  :  10.1088/1742-6596/438/1/012015

来源: IOP

【 摘 要 】

In this work we review and further develop a semiempirical model recently proposed for the ion impact ionization of complex biological media. The model is based on the dielectric formalism, and makes use of a semiempirical parametrization of the optical energy-loss function of bioorganic compounds, allowing the calculation of single and total ionization cross sections and related quantities for condensed biological targets, such as liquid water, DNA and its components, proteins, lipids, carbohydrates or cell constituents. The model shows a very good agreement with experimental data for water, adenine and uracil, and allows the comparison of the ionization efficiency of different biological targets, and also the average kinetic energy of the ejected secondary electrons.