Characterization of elasticity and hydration of composite hydrogel based on collagen-iota carrageenan as a corneal tissue engineering

Asean-Fen International Fisheries Symposium - 2017

Rinawati, M.^1 ; Triastuti, J.^2 ; Pursetyo, K.T.^2

Bachelor Programme of Aquaculture, Faculty of Fisheries and Marine, Universitas Airlangga, Surabaya

60115, Indonesia^1

Department of Marine, Faculty of Fisheries and Marine, Universitas Airlangga, Surabaya

60115, Indonesia^2

关键词: Composite hydrogels;    Corneal tissue engineering;    Equilibrium water contents;    Gelation properties;    Hydration properties;    Hydrogel composites;    Polysaccharide derivatives;    Refractive elements;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/137/1/012042/pdf
DOI  :  10.1088/1755-1315/137/1/012042

来源: IOP

【 摘 要 】

The cornea is a refractive element of the eye that serves to continue the stimulation of light into the eye it has a clear, transparent, elastic and relatively thick tissue. Factors caused corneal blindness, are dystrophy, keratoconus, corneal scaring. Hydrogels can be made from polysaccharide derivatives that have gelation properties such as iota carrageenan. Therefore, it is a need to develop composite hydrogel based collagen-iota carragenan as an engineeried corneal tissue with high elasticity and hydration properties. Collagen hydrogel has a maximum water content an has equlibrium up to 40 %, less than the human cornea, 81 % and under normal hydration conditions, the human cornea can transmit 87 % of visible light. In addition, the refractive index on the surface of the cornea with air is 1.375-1.380. Based on this study, it is necessary to conduct research on the development and composition of hydrogel composite collagen-iota carrageen hydrogen based on. The best result was K5 (5:5) treatment, which has the equilibrium water content of 87.07 % and viscosity of 10.7346 Pa.s.