Hypoglicemic activity of gambier (Uncaria gambir robx.) drinks in alloxan-induced mice

International Conference on Agriculture, Environment, and Food Security

农业科学;生态环境科学

Zebua, E.A.^1 ; Silalahi, J.^2 ; Julianti, E.^1,3

Departement of Food Science, Faculty of Agriculture, Universitas Sumatera Utara, Medan, Indonesia^1

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia^2

Center of Excellence for Marketing Technology of North Sumatera Indigenous Agricultural Product, Universitas Sumatera Utara, Medan

20155, Indonesia^3

关键词: Bioactive compounds;    Blood glucose level;    Body weight;    Distilled water;    Ethyl acetates;    Langerhans;    Male mouse;    Metformins;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/122/1/012088/pdf
DOI  :  10.1088/1755-1315/122/1/012088

来源: IOP

【 摘 要 】

Diabetes may cause complications in various parts of the body and increase the risk of early death. Gambier contains bioactive compounds and can be used as raw material in preparing gambier drink. The purpose of this study was to extract gambier, to determine the hypoglycemic activity of gambier drinks in alloxan-induced mice. In this study, gambier were extracted by 3 types of solvents with distilled water, ethyl acetate, and ethanol. The gambier drinks was tested on 5 groups of mice wich consisting of 5 male mice. Group 1 was given 0.5% CMC 1%/bw, group 2 was given metformin 65 mg/kg bw, groups 3, 4 and 5 were given gambier drinks with dosage of 100, 200, and 300 mg/kg bw. The results showed that extraction using distiled water produced the best gambier drinks. Gambier drinks with dosage 100, 200 and 300 mg/kg bb given for 15 days decreased the blood glucose level 27.69%, 38.75%, and 50.62% respectively, and increased the body weight 13.14%, 10, 91%, and 10.18% respectively. Treatment with gambier drinks was found to improve the condition of pancreatic langerhans island of alloxan-induced mice.