Preliminary investigation on the occurrence of several sulfonamide antibiotics in the Haihe River Basin of China

3rd International Conference on Water Resource and Environment

地球科学;生态环境科学

Zhang, S.L.^1 ; Zhang, J.^1 ; Wang, Z.G.^1 ; Wang, Y.Z.^1 ; Liang, S.T.^1 ; Liu, C.^1,2 ; Wang, Z.^1

Haihe River Water Conservancy Commission, Ministry of Water Resources, Tianjin

300170, China^1

College of Conservancy and Hydropower, Hebei University of Engineering, Handan, Hebei

056038, China^2

关键词: Gradient elution;    Haihe River basin;    Limits of detection;    Liquid chromatography with tandem mass spectrometries;    Maximum concentrations;    Multiple reaction monitoring;    Solid-phase extraction;    Sulfonamide antibiotics;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/82/1/012024/pdf
DOI  :  10.1088/1755-1315/82/1/012024

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

Several samples collected from lakes, rivers and reservoirs in Haihe river basin of China were analyzed for 8 sulfonamide antibiotics by using solid-phase extraction and liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). All water samples were enriched with HLB extraction cartridges. The antibiotics were separated by gradient elution with methanol as the mobile phase adding 0.1% formic acid. The eluate was then analyzed by the mode of multiple reaction monitoring (MRM). The limits of detection (LOD) and quantification (LOQ) were 0.4-1.0 ng/L and 1.0-3.0 ng/L respectively. The method was used for the analysis of 13 samples from Haihe river basin in China. The results showed that sulfamethoxazole was present in all water samples with maximum concentration of 107.59 ng/L. Sulfadiazine was also frequently detected, concentrations ranging from 2.81 ng/L to 85.35 ng/L. Other sulfonamide antibiotics were not detected in most water samples, especially for those samples from drinking water resources.