Evaluation of anti-fatigue and immunomodulating effects of quercetin in strenuous exercise mice

3rd International Conference on Energy Materials and Environment Engineering

能源学;生态环境科学

Zhang, Wei-Qiang^1

Teaching and Research Department, P.E. Central South University, Changsha City, Hunan Province

410083, China^1

关键词: Anti-fatigue;    Biochemical parameters;    Blood glucose;    Immune function;    Interleukin-10;    Retention time;    Tumor necrosis factor alpha;    Urea nitrogen;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/61/1/012046/pdf
DOI  :  10.1088/1755-1315/61/1/012046

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

The purpose of the present study was to investigate the anti-fatigue and immunomodulating effects of quercetin in strenuous exercise mice. Mice were given orally either corn oil or quercetin (20, 40 and 60 mg/kg body weight suspended in corn oil) by gavage once a day for 28 day. All mice were sacrificed after rotarod test and the major biochemical parameters were analyzed in serum and liver. The results indicated that quercetin possessed anti-fatigue effects by prolonging retention times, decreasing levels of blood lactate and serum urea nitrogen, and increasing levels of blood glucose, tissue glycogen and serum glucagon. Furthermore, quercetin could improve the immune function of fatigue mice by decreasing tumor necrosis factor-α levels, and elevated interleukin-10 levels. Quercetin possessed anti-fatigue effects may be related to its immunomodulating effects.