Genetic diversity of feline leukemia virus

International Scientific Conference «AGRITECH-2019: Agribusiness, Environmental Engineering and Biotechnologies»

农业科学;生态环境科学;生物科学

Komina, A.K.^1 ; Zaberezhny, A.D.^1 ; Kucheruk, O.D.^1 ; Zhukova, E.V.^1 ; Guliukina, I.A.^1

K.I. Skryabin and Y.R. Kovalenko Federal Research Center, All-Russian Institute of Experimental Veterinary Medicine (VIEV), Russian Academy of Science, Moscow, Russia^1

关键词: Genetic diversity;    Recombination events;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/315/4/042038/pdf
DOI  :  10.1088/1755-1315/315/4/042038

来源: IOP

【 摘 要 】

Feline Leukemia Virus (FeLV) belongs to retrovirus family, causing various proliferative and immunosuppressive diseases in felines. There are two forms of FeLV: endogenous (enFeLV) and exogenous (exFeLV), the latter has 4 subgroups: A, B, C and T with different receptor specificity. The FeLV-A is the most abundant transmissive form. The FeLVB emerged as a recombinant between provirus FeLV-A and endogenous virus of domestic cats. The FeLV-C appeared as a result of accumulation of mutations in the env FeLV-A gene. The chimeric FeLV-T virus was obtaind as recombination event between 61E and 61C viruses. This review also covers two new recently described subgroups - FeLV-D TG35.