Kinetic and mechanistic study of alanine oxidation by N-chlorosuccinimide using Mn2+ as catalyst.

2nd International Scientific Conference (Pure Sciences, Brilliant Creativity and Renewed Building)

Salman, Noori Y.^1 ; Ibrahim Al-Niami, Kisma H.^2

University of Kufa, Faculty of Pharmacy, Iraq^1

University of Kufa, Faculty of Dentistry, Iraq^2

关键词: Effect of addition;    First order reactions;    Mechanistic studies;    N-chlorosuccinimide;    Oxidation reactions;    Rate of oxidations;    Reaction mechanism;    Reactive species;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/571/1/012076/pdf
DOI  :  10.1088/1757-899X/571/1/012076

来源: IOP

【 摘 要 】

Kinetic studies of oxidation of alanine by N-chlorosuccinimide (NCIS) have been investigated at different pH's. The reaction shows consecutive first order reaction with respect to both oxidant and substrate. Fractional order were observed in hydrogen ion and manganeseion. Slight effect of addition of reaction product (succinimide) on the rate of oxidation reaction have been noticed. Changing the ionic strength had no effect on the rate of oxidation reaction. Cl+ or NClS and NClS protonated were suggested to be the reactive species of N-chlorosuccinimide. An intermediates compounds have been found and proved by using michaelis menton equation. A reaction mechanism for the oxidation reaction was suggested.