The effect of auricular electro-stimulation as compared with diazepam in seizure attack reduction in epilepsy rat model induced by pilocarpine

2nd International Scientific Conference (Pure Sciences, Brilliant Creativity and Renewed Building)

Farhan, Noor Hadi^1 ; Almaali, Hasan Abo^1

Department of Clinical Laboratory Science. College of Pharmacy, Karbala University, Karbala, Iraq^1

关键词: Alternative management;    Beneficial effects;    Complex effects;    Control groups;    Electrical stimulations;    Pharmacological treatment;    Rat model;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/571/1/012044/pdf
DOI  :  10.1088/1757-899X/571/1/012044

来源: IOP

【 摘 要 】

The efficacy of electro stimulation in epilepsy remained to be approved due to the diversity and complex effect which induced by this alternative management. So that, the objective of the study was to demonstrate the anticonvulsant methods of electro stimulation of ear points in rat with lab experimental seizure. To achieve this goal, the epilepsy rats' model was prepared by intra peritoneal injection of pilocarpine. Seizure rats, would be stimulated electrically, it simulated as ear-point electrical stimulation with rats that treated with diazepam as a pharmacological treatment. The results revealed that the convulsion behaviours were improved in comparison to control group, but the beneficial effect was lesser than diazepam treated rat group. Basing on the results that obtained, it suggested that the electrical stimulation of certain ear-point had weak effect as anti-epilepsy, that might be get involved in decreasing the epilepsy attacks as an attempt to use a non-pharmacological management to improve epilepsy in combination with other stimulation points or longer periods.