Synthesis and study of antibacterial activity of polyeugenol

13th Joint Conference on Chemistry

Prasetya, Nor Basid Adiwibawa^1 ; Ngadiwiyana^1 ; Ismiyarto^1 ; Sarjono, Purbowatiningrum Ria^1

Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Semarang, Indonesia^1

关键词: Anti-bacterial activity;    antibacterial;    Degree of polymerisation;    Disc diffusion methods;    Eugenol;    Nitrogen atmospheres;    Polyeugenol;    Staphylococcus aureus;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/509/1/012101/pdf
DOI  :  10.1088/1757-899X/509/1/012101

来源: IOP

【 摘 要 】

Research on synthesis and study of antibacterial activity of polyeugenol has been carried out. The synthesis of polyeugenol was carried out by cationic polymerization using a BF3 catalyst at room temperature under nitrogen atmosphere. The resulting polyeugenol is brownish and not soluble in water but in acetone, chloroform, DMSO and benzene solvents. Molecular weight of Polyeugenol using Ubbelohde is 9728 g mol-1 to find a degree of polymerisation (DP) of 60. Antibacterial test was carried out by comparing the activity of polypugenol synthesized against Escherichia coli and Staphylococcus aureus with disc diffusion method. In this study, ampicillin was used as a positive control and DMSO was used as a negative control. The test result showed that polyeugenol still has antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria with a slow response category.