Characterized and synthesis of chitosan nanoparticle as nanocarrier system technology

Tarumanagara International Conference on the Applications of Technology and Engineering

工业技术（总论）

Wijayadi, Linda Julianti^1 ; Rusli, Taty Rusliati^2

Dermatovenereology Division, Universitas Tarumanagara, Jakarta

11440, Indonesia^1

Chemistry Division, Universitas Tarumanagara, Jakarta

11440, Indonesia^2

关键词: Active agents;    Biomedical fields;    Chitosan nanoparticles;    Degree of deacetylation;    Drug permeation;    Natural materials;    Polydispersity indices;    Therapeutic efficacy;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/508/1/012143/pdf
DOI  :  10.1088/1757-899X/508/1/012143

学科分类：工业工程学

来源: IOP

【 摘 要 】

Chitosan is a natural material produced by deacetylation of chitin from crustacean exoskeleton. Being biocompatible, biodegradable, and affordable, chitosan is widely explored in biomedical field as active agent or drug carrier. Nanoparticles with its unique physicochemical properties, have great potential to maximize therapeutic efficacy. This study used chitosan nanoparticles made by ionotrophic gelation technique. The aim of this study was to characterized chitosan nanoparticles for particle size, surface morphology and degree of deacetylation. The chitosan nanoparticles diameter size was 48nm with polydispersity index was 0,289 and degree of deacetylation less than 75%. Therefore, chitosan nanoparticle is a promising nanocarrier system for drug delivery to enhance drug permeation.