Comparative Properties of Hyaluronic Acid Hydrogel Cross-linked with 1, 4-Butanediol Diglycidyl Ether Assayed Using a Marine Hyaluronidase

2nd International Conference on Frontiers of Materials Synthesis and Processing

Chang, Liuyi^1 ; Zhang, Jingliang^2^3 ; Jiang, Xiaolu^1^3

College of Food Science and Engineering, Ocean University of China, Qingdao, China^1

College of Medicine and Pharmacy, Ocean University of China, Qingdao, China^2

Marine Biomedical Research Institute of Qingdao, Qingdao, China^3

关键词: 1 ,4-butanediol diglycidyl ethers;    Arthrobacter globiformis;    Cross-linkers;    Hyaluronic acid hydrogels;    Marine bacterium;    Modification degrees;    Spatial network;    Swelling degree;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/493/1/012007/pdf
DOI  :  10.1088/1757-899X/493/1/012007

来源: IOP

【 摘 要 】

Hyaluronic acid (HA) hydrogels for injection were fabricated using 1, 4-butanediol diglycidyl ether (BDDE) as a cross-linker. We used hyaluronidase fermented by the marine bacteria Arthrobacter globiformis A152, to comprehensively investigate the effects of BDDE concentration on swelling degree, modification degree, morphology, HA content, anti-enzyme ability, and residual free cross-linker. The results showed that within a certain range, the measured modification degrees of the HA hydrogels and HA contents changed linearly with increased concentration of the cross-linker. However, the change in anti-enzyme ability was not linear, potentially reflecting the influence of the spatial network structure.