68Ga-adsorption on the Si-nanoparticles

2nd International (15th Regional) Scientific Conference "Technogenic Systems and Environmental Risk"

工业技术（总论）;生态环境科学

Skrabkova, H.S.^1^3 ; Bubenschikov, V.B.^2 ; Kodina, G.E.^2 ; Lunev, A.S.^2 ; Larenkov, A.A.^2 ; Epshtein, N.B.^3 ; Kabashin, A.V.^4

Chemistry Department, Belarusian State University, Minsk

375-17-226-59-40, Belarus^1

Burnasyan Federal Medical Biophysical Center, Moscow, Russia^2

Obninsk Institute for Nuclear Power Engineering National, Research Nuclear University MEPhI, Obninsk, Russia^3

Aix-Marseille University, Marseille Cedex 9, France^4

关键词: Drug delivery system;    In-vitro;    Nanoparticle (NPs);    Radiochemical yield;    Si nanoparticles;    Silicon-based;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/487/1/012026/pdf
DOI  :  10.1088/1757-899X/487/1/012026

来源: IOP

【 摘 要 】

In recent years, more and more attention has been paid to nanoparticles (NPs) as target drug delivery systems. Silicon-based nanoparticles are one of the most biocompatible nanomaterials that have become widespread. In this research, we studied the possibility of gallium-68 sorption on silicon (Si-SiOx) and silicon dioxide (SiO2) nanoparticles without their surface modification. Conditions allowing to obtain 68Ga-NPs with radiochemical yield ≥ 90% were found. 68Ga-SiO2 showed much higher stability over 68Ga-Si-SiOx in both in vitro and in vivo experiments.