会议论文详细信息
3rd International Workshop on Biological Processes & Petri Nets, a satellite event of PETRI NETS 2012
Modelling Atopic Dermatitis using Petri Nets
Marta E Polak
Others  :  http://ceur-ws.org/Vol-852/paper6.pdf
PID  :  43084
来源: CEUR
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【 摘 要 】

Atopic dermatitis (AD) is a disorder of inflammation in the skin and is strongly associated with other inflammatory epithelial atopic conditions (asthma, allergic rhinitis and food allergy). The pathogenesis of AD results from complex interactions between susceptibility genes encoding skin barrier molecules and markers of the inflammatory response, host environments, infectious agents, and specific immunologic responses [1-3]. Despite the long-held knowledge about the multiple immunological processes involved in AD pathogenesis (including role of dendritic cells, kerationocytes and T lymphocytes, interactions between different cell types, effect of allergen exposure, trauma and infection with Staphylococcus Aureus on the AD exacerbations) the precise reason for the bias towards a cutaneous Th2 response in AE still remains obscure. It seems likely that understanding of the complex cross-talk between different components of the cutaneous immune network is fundamental to understanding of the Th2 polarised inflammation in AD.

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