PROCEEDINGS Open Access Comparison of methods for estimation of genetic covariance matrix from SNP or pedigree data utilised to predict breeding value

13th European workshop on QTL mapping and marker assisted selection

生物科学;医药卫生

Sebastian Mucha ; Anna Wolc ; Tomasz Strabel

Others  :  http://www.biomedcentral.com/content/pdf/1753-6561-4-S1-S7.pdf
PID  :  49506

来源: CEUR

【 摘 要 】

Background: The aim was to predict breeding values of non-ph enoty ped in dividuals ba sed on a da taset prepar for the 13th QT L-MAS Work shop in Wageni ngen. Met hods:Genetic co-varian ce matrices betw een animal s were estimat ed with thre e method s: one using pedigre informa tion only and two bas ed on SNP markers from the first chromo some. Quadrat ic regressi on of bree ding value s, estimate d separately in ea ch of the five time poin ts, was used to predict the bree ding value s in the 6th time point. Results: Base d on the compa rison (true - estimate d BV) it can be conclud ed that SNP based me thods provide d bette r estimate s (accu racy between 0.75 and 0.80 ) than pedigre e (0.65).Conclusions : Even though only SNPs from chro mosome 1 were used it was still possible to ach ieve fairl y high accura cies. Mo st like ly this was due to the fact that chrom osome 1 contained the QTLs with the large st ef fects.[First Paragraph]