Proceedings ebTrack: an environmental bioinformatics system built upon ArrayTrack™

First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES-2007)

生物科学;医药卫生

Minjun Chen ; Jackson Martin ; Hong Fang ; Sastry Isukapalli ; Panos G Georgopoulos ; William J Welsh ; Weida Tong

Others  :  http://www.biomedcentral.com/content/pdf/1753-6561-3-S2-S5.pdf
PID  :  49526

来源: CEUR

【 摘 要 】

ebTrack is being developed as anintegrated bioinformatics system for environmental research andanalysis by addressing the issuesof integration, curation, man agement, first level analysis andinterpretation of environmentaland toxicological data from diverse sources. It is based on enhancements to the US FDA developed ArrayTrack™ system through additional analysis modules for gene expression data as well as through inco rporation and linkages to modules for analysis of proteomic and metabonomic datasets that include tandem mass spectra. ebTrack uses a client-server architecture with the free and open source PostgreSQL as its database engine, and java tools for user interface, analysis, visu alization, and web-based deployment. Several predictive tools that are critical for environmental health researchare currently supported in ebTrack, including Significance Analysis of Mi croarray (SAM). Furthermore,new tools are under continuous integration, and interfaces to en vironmental health risk analysistools are being developed in order to make ebTrack widely usable. These health risk analysis tools include th e Modeling ENvironment for TOtal Risk studies (MENTOR) for source-to-dose exposure modeling and the DOse Response Information ANalysis system (DORIAN) for health outcome modeling. The design of ebTrack ispresented in detail and steps involved in itsapplication are summarized through an illustrative application.[First Paragraph]