Proceedings Systems biology for identify ing liver toxicity pathways

First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES-2007)

生物科学;医药卫生

Zheng Li ; Christina Chan

Others  :  http://www.biomedcentral.com/content/pdf/1753-6561-3-S2-S2.pdf
PID  :  49522

来源: CEUR

【 摘 要 】

Drug-induced liver to xicity is one of the leading causes of ac ute liver failure in the United States, exceeding all other causes combined. The objective of this paper is to describe systems biology methods for identifying pathwaysinvolved in liver toxicity induce d by free fatty acids (FFA) and tumor necrosis factor (TNF)- αin human hepatoblastoma cell s (HepG2/C3A). Systems biology approaches were developed to integrate multi-leve l data, i.e., gene expression, metabolite profile, toxicity measurements and a prioriknowledge to identify gene targ ets for modulating liver toxicity. Targets that modulate liver toxicity, in vitro , were computationally predicted and some targets were experimentally validated.[First Paragraph]