会议论文详细信息
The Fourth Annual Meeting of the Dermatology Forum for Basic Research and Treatment
Tissue Regeneration: Hair Follicle as a Model
Shigetoshi Sano ; Junji Takeda ; Kunihiko Yoshikawa ; Satoshi Itami
Others  :  http://www.nature.com/jidsp/journal/v6/n1/pdf/5640024a.pdf
PID  :  5307
来源: CEUR
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【 摘 要 】

The Cre-loxP strategy has allowed us to generate the mice whose keratinocytes are devoid of Stat3, which play a pivotal role in the signal transduction following the stimulation with various growth factors/ cytokines, such as EGF, HGF, or IL-6. Although keratinocyte-speci®c Stat3-disrupted mice were born normal with intact skin and the ®rst hair cycle, they exhibited retardation of wound healing and absence of the second hair cycle onward, leading to development of spontaneous skin ulcers and alopecia as they aged. Thus, analyses of these mice reveal that Stat3 in keratinocytes contributes to the regeneration of epidermis and hair cycle process. [First Paragraph]

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