This year, PSB returns to its most common venue, the Fairmont Orchid on the Big Island of Hawaii. We are now in our thirteenth year, and had a record number of both proposed sessions (we accepted 9) as well as submissions to the conferencethisyear(150).Manysessions at PSB have a lifetime of approximately three years. The first year is a test of the interest in the field, and the ability to attract a critical mass of papers. With success, the second year is usually a larger, more competitive session. The third (and rarely fourth years) usually come as the subdisciplineis recognized atthe general biocomputing meetings such as ISMB, RECOMB and others, and often this is when the PSB organizers conclude that their work is done, and the session can be "retired." PSBaficionadoswillnoticenewsessionsthisyearinnext-generation sequencing, tiling array analysis, multiscale modeling, small regulatory RNAs, and other areas. The richness of exciting new areas has led us to have more total sessions,andthustheaverage session size is smaller. We consider this an experiment, and look forward to seeing how it goes.